10x Genomics
Chromium Single Cell Immune Profiling

Cell Ranger2.0, printed on 12/18/2024

What is Loupe™ V(D)J Browser?

Introduction

Loupe V(D)J Browser is a desktop application for Windows and MacOS that allows you to analyze, search, and visualize V(D)J sequences and clonotypes from single cell 5′ data produced by the 10x Chromium Platform. You can use it to quickly explore the clonality and diversity of T-cell receptors at the single-cell level. Loupe is named for a jeweler's loupe, which is used to inspect gems.

	10x Chromium	Sequencer	10x Cell Ranger	10x Loupe V(D)J Browser
Cell Suspension	Barcoding & Library Construction	Sequence library	Pipelines	Analysis & Visualization

Within Loupe V(D)J Browser, you will be able to quickly determine the most common paired alpha and beta TCR chains or heavy and light BCR chains within your sample, search for motifs within CDR3 regions, detect variants within V(D)J transcripts, and validate read support for clonotype consensus sequences through an embedded version of IGV.js:

To find out how to use Loupe V(D)J Browser to explore your lymphocyte data, start the tutorial.